A series of real-life individuals with HIV appears to tell their stories, several of whom appear to be LGBT. The ad introduces Garland, Jack, Peter, Leo, and Jeanette. Leo appears to work in theater and we see him apply makeup before walking out on stage in costume. The people later show up in various outdoor sites of NYC, including Peter in Coney Island and Jack working out at a park along the Hudson River.
The commercial follows an integrated media campaign with more information about each person.
According to FiercePharma, there have been no other branded HIV drugs in recent history that have aired TV spots. making this one unique.